The blood transcriptome of childhood malaria
نویسندگان
چکیده
منابع مشابه
Mining the malaria transcriptome.
Malaria remains the most devastating parasitic disease worldwide, and is responsible each year for >500 million infections and between one million and two million deaths of children under five years of age. Plasmodium falciparum is the most prevalent and deadly malaria parasite of humans, and a huge amount of data about it is now publicly available following completion of its genome sequence, t...
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The World Health Organization has estimated that in 2015 there were 214 million cases of malaria that led to approximately 438,000 deaths. The development of novel therapeutics largely relies on a better understanding of parasite biology and pathogenesis. Our analyses on time-series RNA-Seq data identified stage-specific genes expressed across the blood-stage in the malaria parasite, Plasmodium...
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Malaria parasites are highly virulent pathogens which infect a wide range of vertebrates. Despite their importance, the way different hosts control and suppress malaria infections remains poorly understood. With recent developments in next-generation sequencing techniques, however, it is now possible to quantify the response of the entire transcriptome to infections. We experimentally infected ...
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Most studies of gene expression in Plasmodium have been concerned with asexual and/or sexual erythrocytic stages. Identification and cloning of genes expressed in the preerythrocytic stages lag far behind. We have constructed a high quality cDNA library of the Plasmodium sporozoite stage by using the rodent malaria parasite P. yoelii, an important model for malaria vaccine development. The tech...
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Hepatic function of 80 children aged under 3 years with Plasmodium vivax malaria were studied during the acute attack and 6 weeks after antimalarial treatment. Raised levels of serum aspartate transaminase (serum AST; SGOT), serum alanine transaminase (serum ALT; SGPT), and alkaline phosphatase were observed in 68%, 39% and 46% of cases respectively. AST levels were higher than ALT ones and the...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2019
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2018.12.055